ICAM5, also known as telencepahlin, is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. ICAM5 is expressed on the surface of telencephalic neurons and displays two types of adhesion activity, homophilic binding between neurons and heterophilic binding between neurons and leukocytes. It may be a critical component in neuron-microglial cell interactions in the course of normal development or as part of neurodegenerative diseases [taken from NCBI Entrez Gene (Gene ID: 7087)]. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9UMF0].