Protocadherin Fat 1 is an ortholog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. FAT1 is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, FAT1 has five epidermal growth factor (EGF)-like repeats and one laminin A-G domain. FAT1 is expressed at high levels in a number of fetal epithelia. Its product probably functions as an adhesion molecule and/or signaling receptor, and is likely to be important in developmental processes and cell communicatio [taken from NCBI Entrez Gene (Gene ID: 2195)].