Topoisomerases regulate topological states of DNA and are divided into type I and type II enzymes. Type II topoisomerases make double stranded breaks in DNA and allow the passage of another duplex DNA across the break to achieve unknotting of entangled DNA. Topo II beta is one of two described isoforms that are likely products of a gene duplication event. TopoII beta is also described to be involved in chromosome condensation, chromatid separation, and the relief of supercoil stress.
DNA topoisomerase 2-beta•
DNA topoisomerase II, 180 kD•
DNA topoisomerase II, beta isozyme•
topo II beta•
topoisomerase (DNA) II beta 180kDa•
topoisomerase II beta•
U937 associated antigen•