TAR RNA-binding protein 1 (TARBP1) is a probable S-adenosyl-L-methionine-dependent methyltransferase which methylates RNA molecules such as tRNAs. In case of infection by HIV-1, it binds to the loop region of TAR RNA, a region also bound by RNA polymerase II. Binding of TARBP1 and RNA polymerase II to HIV-1 TAR RNA is mutually exclusive, suggesting that TARBP1 may function alone or in conjunction with HIV-1 Tat to disengage RNA polymerase II from HIV-1 TAR RNA. TARBP1 may act by methylating HIV-1 TAR RNA [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q13395].
probable methyltransferase TARBP1•
TAR (HIV) RNA-binding protein 1•
TAR RNA loop binding protein•
TAR RNA-binding protein 1•
TAR RNA-binding protein of 185 kDa•
tRNA methyltransferase 3 homolog•