Rictor Antibody

Rictor is a subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays an essential role in embryonic growth and development [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q6R327].
RICTOR
RPTOR independent companion of MTOR complex 2
Rapamycin-insensitive companion of mTOR
:  AVO3 AVO3 homolog hAVO3 KIAA1999 MGC39830 PIA pianissimo rapamycin-insensitive companion of mTOR RPTOR independent companion of MTOR, complex 2 TORC2-specific protein AVO3
Product
Specifications
Ordering Information
Human
WB, IP
Between 1 and 50
$339
$229
$99
Human, Mouse
WB, IP, IHC
Between 1650 and C-term
$339
$229
$99
Human
IP, IHC
Between 1 to 50
$339
$99
Human
IP
Between 1 and 50
$356
Human, Mouse
IP
Between 1650 and C-term
$364
Human, Mouse
WB, IP, IHC
Includes: 1 each of A300-458A, A300-459A and A304-329A
$707
Includes: 1 each of A300-458A, A300-459A and A304-329A
Human
IHC
Between 1650 and C-term
$360
$99
Human
WB, IP, IHC, ICC, PLA
Between 1650 and C-term
$229
$99