CSN3 Antibody

CSN3 is one of eight subunits (CSN1 to 8) of the highly conserved COP9 signalsome (CSN) complex originally identified as a regulator of light-mediated development in Arabidopsis. Characterization of CSN from yeast to mammals reveals its function as a modulator of signal transduction pathways involved in a variety of cellular and developmental processes. One of the major functions of the CSN is the regulation of protein degradation via intersection with the ubiquitin-proteasome pathway and regulation of E3-ubiquitin ligases. The CSN also possesses kinase activity. CSN3 is the kinase associated with the CSN complex that phosphorylates signal transducers such as I-kappa-Balpha, p105, and c-Jun. Human CSN3 maps to the Smith-Magenis syndrome locus. Microdeletions in this locus results in mental retardation, skeletal abnormalities, sleep disorder, and neurobehavior anomalies.
COPS3
COP9 signalosome subunit 3
COP9 signalosome complex subunit 3
:  COP9 (constitutive photomorphogenic, Arabidopsis, homolog) subunit 3 COP9 complex subunit 3 COP9 constitutive photomorphogenic homolog subunit 3 COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis) CSN3 JAB1-containing signalosome subunit 3 SGN3 signalosome subunit 3 More... Less...
Product
Specifications
Ordering Information
Human
WB, IHC
Between 325 and 375
$339
$229
$99
Human
WB
Between 325 and 375
$339
$229
$99
Human
WB, IHC
Includes: 1 each of A300-012A and A300-029A
$472
Includes: 1 each of A300-012A and A300-029A
Human
IHC
Between 325 and 375
$360
$99