Due to inclement weather, Bethyl will be closed Tuesday, January 16 and re-open Wednesday, January 17th at noon. Orders will not be processed until Bethyl re-opens. This is a developing weather situation and may continue to change. Thank you!
AATF/Che-1 was identified as a protein that interacts with RNA polymerase II and is involved in the regulation of gene transcription and cell proliferation. AATF/Che-1 has been demonstrated to promote cell proliferation by acting as a competitor of histone deacetylase 1 (HDAC1) and interfering with HDAC1’s interaction with the growth inhibiting protein pRB. AATF has also been shown to function as a nuclear receptor coactivator and a repressor of apoptosis.