TS Antibody

Thymidylate synthetase (TS) catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. TS is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs [taken from NCBI Entrez Gene (Gene ID: 7298)].
TYMS
thymidylate synthetase
Thymidylate synthase
:  HsT422 TMS TS Tsase
Product
Specifications
Ordering Information
Human, Mouse
WB, IP, IHC
Between 263 to 313
$339
$229
$99