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PAN2/USP52 Antibody

PAB-dependent poly(A)-specific ribonuclease subunit PAN2 is the catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein (PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1 [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q504Q3].
PAN2
poly(A) specific ribonuclease subunit PAN2
PAB-dependent poly(A)-specific ribonuclease subunit PAN2
:  inactive ubiquitin carboxyl-terminal hydrolase 52 PAB1P-dependent poly(A)-nuclease PAB1P-dependent poly(A)-specific ribonuclease PAB-dependent poly(A)-specific ribonuclease subunit 2 PAB-dependent poly(A)-specific ribonuclease subunit PAN2 PABP-dependent poly(A) nuclease 2 PAN deadenylation complex catalytic subunit 2 PAN deadenylation complex subunit 2 PAN2 poly(A) specific ribonuclease subunit homolog PAN2 polyA specific ribonuclease subunit PAN2-PAN3 deadenylation complex catalytic subunit PAN2 poly(A)-nuclease deadenylation complex subunit 2 ubiquitin specific peptidase 52 ubiquitin specific protease 52 USP52 More... Less...
Product
Specifications
Ordering Information
Human, Mouse
WB, IP
Between 1 and 50
$350
$236
$99