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Outer dense fiber protein 2 (ODF2) seems to be a major component of sperm tail outer dense fibers (ODF). ODFs are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail. ODF2 functions as a general scaffold protein that is specifically localized at the distal/subdistal appendages of mother centrioles. ODF2 is a component of the centrosome matrix required for the localization of PLK1 and NIN to the centrosomes and is required for the formation and/or maintenance of normal CETN1 assembly [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q5BJF6].