APC Antibody

Adenomatosis polyposis coli (APC) is a tumor suppressor gene found to be mutated in most colon cancers and is the cause of familial adenomatous polyposis (FAP), an autosomal dominant disease that results in a predisposition to malignant colon cancer. APC has been shown to be involved in cell differentiation, migration, proliferation and adhesion. One function of APC involves its role as a scaffolding protein that regulates the phosphorylation and degradation of beta-catenin, a transcriptional regulator in the WNT signaling pathway. Additionally, APC has been found to be important in the regulation of microtubule arrays and mitotic spindle formation.
APC
adenomatous polyposis coli
Adenomatous polyposis coli protein
:  adenomatosis polyposis coli adenomatosis polyposis coli tumor suppressor BTPS2 deleted in polyposis 2.5 DP2 DP2.5 DP3 GS PPP1R46 Protein APC protein phosphatase 1, regulatory subunit 46 truncated adenomatosis polyposis coli
Product
Specifications
Ordering Information
Human
IP, IHC
Between 1 and 50
$339
$99
Human
IP, IHC
Between 75 and 125
$339
$99
Human
IP, IHC
Between 2793 and C-term
$339
$99
Human
WB, IP, IHC
Includes: 1 each of A300-979A, A300-980A and A300-981A
$707
Includes: 1 each of A300-979A, A300-980A and A300-981A
Human
IHC
Between 1 and 50
$360
$99