BRCA2 was identified as a gene with germline mutations that predisposes women to breast cancer. An important function of BRCA2 involves its direct interaction with RAD51 and the process of homologous recombination in DNA double strand break repair. BRCA2 and BRCA1 primary sequences are not similar; however the proteins exhibit similar patterns of expression and sub-cellular localization. Although the phenotype of disruptions of BRCA2 is similar to BRCA1, BRCA2 appears to possess functions distinct from BRCA1.
BRCA1/BRCA2-containing complex, subunit 2•
breast and ovarian cancer susceptibility gene, early onset•
breast and ovarian cancer susceptibility protein 2•
breast cancer 2 tumor suppressor•
breast cancer 2, early onset•
Fanconi anemia group D1 protein•
Fanconi anemia, complementation group D1•