Synoviolin Antibody

The E3 ubiquitin-protein ligase synoviolin is also known as human HRD1. The original HRD1 (HMG-CoA reductase degradation) gene was identified as a mutant gene in yeast deficient for the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR). Homology between the human and yeast gene is limited to the N-terminal domain of the proteins, and human HRD1/Synoviolin does not appear to be involved in the degradation of mammalian HMGR. Synoviolin is involved in endoplasmic reticulum (ER)-associated degradation. It removes unfolded proteins, accumulated during ER stress, by retrograde transport to the cytosol from the ER. This protein also uses the ubiquitin-proteasome system for additional degradation of unfolded proteins.
SYVN1
synoviolin 1
E3 ubiquitin-protein ligase synoviolin
:  DER3 HMG-coA reductase degradation 1 homolog HMG-coA reductase degradation 1 homolog (S. cerevisiae) HRD1 Synovial apoptosis inhibitor 1 synovial apoptosis inhibitor 1, synoviolin
Product
Specifications
Ordering Information
Human
IP
Between 550 and 600
$339
$99
Human, Mouse
WB, IP
Between 567 and 617
$339
$229
$99
Human, Mouse
WB, IP
Includes: 1 each of A302-945A and A302-946A
$472
Includes: 1 each of A302-945A and A302-946A