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SPG8/Strumpellin Antibody

SPG8/Strumpellin acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes seems to inhibit WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization involved in regulation of the fission of tubules that serve as transport intermediates during endosome sorting (PubMed:19922875, PubMed:20498093). SPG8/Strumpellin may be involved in axonal outgrowth [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q12768].
WASH complex subunit strumpellin
:  RTSC RTSC1 spastic paraplegia 8 (autosomal dominant) SPG8 strumpellin
Ordering Information
Human, Mouse
Between 1109 and 1159