JMY Antibody

Junction-mediating and -regulatory protein (JMY) acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In the nucleus, JMY acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300 and increases p53/TP53-dependent transcription and apoptosis suggesting an important role in p53/TP53 stress response such as DNA damage. In the cytoplasm, JMY acts as a nucleation-promoting factor for both branched and un-branched actin filaments. It activates the Arp2/3 complex to induce branched actin filament networks and also catalyzes actin polymerization in the absence of Arp2/3, creating un-branched filaments [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q8N9B5].
JMY
junction mediating and regulatory protein, p53 cofactor
Junction-mediating and -regulatory protein
:  FLJ37870 junction-mediating and regulatory protein WAS protein homology region 2 domain containing 1-like 3 WHAMM2 WHDC1L3
Product
Specifications
Ordering Information
Human
IP, IHC
Between 1 and 50
$339
$99
Human
WB
Between 800 and 850
$339
$229
$99
Human
WB, IP, IHC
Includes: 1 each of A302-572A and A302-573A
$472
Includes: 1 each of A302-572A and A302-573A
Human
IHC
Between 1 and 50
$360
$99