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PTPN11/Shp2 Antibody

PTPN11/Shp2 is a src-homology 2-containing protein-tyrosine phosphatase (PTP). PTPN11/Shp2 is a non-receptor phosphatase that mediates a variety of cytokine, growth factor, and hormone signals. Signal transduction by PTPN11/Shp2 is achieved via the activation of the Ras/mitogen-activated protein kinase pathway. Heterogenous gain of function mutations in PTPN11/Shp2 are associated with juvenile myelomonocytic leukemia (JMML) and Noonan syndrome, a disorder characterized by short stature, facial dysmorphology, and congenital heart defects.
protein tyrosine phosphatase, non-receptor type 11
Tyrosine-protein phosphatase non-receptor type 11
:  BPTP3 CFC JMML METCDS NS1 protein-tyrosine phosphatase 1D protein-tyrosine phosphatase 2C PTP-1D PTP2C PTP-2C SHP2 SHP-2 SH-PTP2 SH-PTP3 tyrosine-protein phosphatase non-receptor type 11
Ordering Information
Human, Mouse
between 543 and 593