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PKC-eta Antibody

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. PKC-eta is one of the PKC family members. It is a calcium-independent and phospholipids-dependent protein kinase. It is predominantly expressed in epithelial tissues and has been shown to reside specifically in the cell nucleus. PKC-eta can regulate keratinocyte differentiation by activating the MAP kinase MAPK13 (p38delta)-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alpha (CEBPA). It is also found to mediate the transcription activation of the transglutaminase 1 (TGM1) gene [taken from NCBI Entrez Gene (Gene ID: 5583)].
PRKCH
protein kinase C eta
Protein kinase C eta type
:  nPKC-eta PKCL PKC-L PRKCL protein kinase C eta type
Product
Specifications
Ordering Information
Human
IP
Between 300 and 350
$350
$99
Human
WB, IP
Between 633 and 683
$350
$236
$99