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MDR1/ABCB1 Antibody

Multidrug resistance protein 1 (MDR1) is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). MDR1 is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. MDR1 is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. MDR1 also functions as a transporter in the blood-brain barrier [taken from NCBI Entrez Gene (Gene ID: 5243)].
ATP binding cassette subfamily B member 1
Multidrug resistance protein 1
:  ABC20 ATP-binding cassette sub-family B member 1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 CD antigen CD243 CD243 CLCS colchicin sensitivity doxorubicin resistance GP170 MDR1 multidrug resistance protein 1 P glycoprotein P-glycoprotein 1 P-GP PGY1
Ordering Information
Between 1 and 50