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ErbB3 Antibody

ErbB3, also known as HER3, is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors[taken from NCBI Entrez Gene (Gene ID: 2065)].
erb-b2 receptor tyrosine kinase 3
Receptor tyrosine-protein kinase erbB-3
:  c-erbB3 c-erbB-3 ErbB-3 erbB3-S HER3 human epidermal growth factor receptor 3 LCCS2 MDA-BF-1 p180-ErbB3 p45-sErbB3 p85-sErbB3 proto-oncogene-like protein c-ErbB-3 receptor tyrosine-protein kinase erbB-3 tyrosine kinase-type cell surface receptor HER3 v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3 More... Less...
Ordering Information
Between 1275 and 1325
Between 1292 and 1342