LIN28B Antibody

Lin-28 homolog B (LIN28B) acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. LIN28B acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7. LIN28B specifically recognizes the 5'-GGAG-3' motif in the terminal loop of pre-let-7. It also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5'-GGAG-3' motif in the terminal loop, leading to their terminal uridylation and subsequent degradation [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q6ZN17].
LIN28B
lin-28 homolog B
Protein lin-28 homolog B
:  CSDD2 FLJ16517 lin-28 homolog B (C. elegans) Lin-28.2 lin-28B
Product
Specifications
Ordering Information
Human
WB, IP
Between 1 and 50
$339
$229
$99
Human
IP, IHC
Between 200 and 250
$339
$99
Human
WB, IP, IHC
Includes: 1 each of A303-588A and A303-589A
$472
Includes: 1 each of A303-588A and A303-589A