STAT1 (signal transducer and activator of transcription 1) is a member of the STAT protein family). In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. STAT1 can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens [taken from NCBI Entrez Gene (GeneID: 6772)].
Signal transducer and activator of transcription 1-alpha/beta
signal transducer and activator of transcription 1, 91kD•
signal transducer and activator of transcription 1, 91kDa•
signal transducer and activator of transcription-1•
transcription factor ISGF-3 components p91/p84•