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PRCC Antibody

In a subset of papillary renal cell carcinomas, a t(X;1)(p11;q21) chromosome translocation has been repeatedly reported and is thought to be the cause of the cancer. As a result of the translocation, the transcription factor TFE3 on the X chromosome becomes fused to the PRCC (papillary renal cell carcinoma translocation-associated) gene on chromosome 1. The fused gene results in the fusion of N-terminal proline-rich region of the protein encoded by this gene to the entire TFE3 protein. This protein has been shown to interact with the mitotic checkpoint protein MAD2B, which suggests that the dominant-negative effect of the fusion protein with TFE3 may lead to a mitotic checkpoint defect [taken from NCBI GeneID:5546].
PRCC
papillary renal cell carcinoma (translocation-associated)
Proline-rich protein PRCC
:  papillary renal cell carcinoma translocation-associated gene protein RCCP1 TPRC
Product
Specifications
Ordering Information
Human
IP, IHC
Between 125 and 175
$339
$99
Human, Mouse
WB, IP
Between 425 and 475
$339
$229
$99
Human, Mouse
WB, IP, IHC
Includes: 1 each of A302-339A and A302-340A
$472
Includes: 1 each of A302-339A and A302-340A
Human, Mouse
IHC
Between 125 and 175
$360
$99