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NP95/UHRF1 Antibody

NP95/UHRF1 was originally identified as ICBP90 (inverted CCAAT box-binding protein of 90 kDa) in a one-hybrid screen for proteins that bind the topoisomerase IIalpha gene promoter. NP95/UHRF1 is a heterochromatin binding protein that directly interacts with histones and has proposed roles in the DNA damage response, heterochromatin formation, and cell replication. Structurally, NP95/UHRF1 contains an ubiquitin-like domain (NIRF_N), a plant homeodomain (PHD), a SRA domain, and a RING domain. The RING domain imparts ubiquitin E3 ligase activity that is histone-specific. This E3 ligase activity is proposed to be important to tumor growth. NP95/UHRF1 expression begins in the G1/S phase and continues through mitosis. It has been shown to be required for entry from G1/G0 as well as the G1/S transition in some cell types. NP95/UHRF1 has been found to be part of the pericentric heterochromatin duplication body (pHDB) and involved in the replication and formation of heterochromatin.
ubiquitin like with PHD and ring finger domains 1
E3 ubiquitin-protein ligase UHRF1
:  E3 ubiquitin-protein ligase UHRF1 hNP95 hUHRF1 huNp95 ICBP90 inverted CCAAT box-binding protein of 90 kDa Np95 nuclear phosphoprotein 95 nuclear protein 95 nuclear zinc finger protein Np95 RING finger protein 106 RING-type E3 ubiquitin transferase UHRF1 RNF106 TDRD22 transcription factor ICBP90 ubiquitin-like PHD and RING finger domain-containing protein 1 Ubiquitin-like-containing PHD and RING finger domains protein 1 More... Less...
Ordering Information
between 275 and 325
Between 275 and 325