Due to inclement weather, Bethyl will be closed Tuesday, January 16 and re-open Wednesday, January 17th at noon. Orders will not be processed until Bethyl re-opens. This is a developing weather situation and may continue to change. Thank you!
Kinesin family member 20B (KIF20B) is a plus-end-directed motor enzyme that is required for completion of cytokinesis (PubMed:11470801, PubMed:12740395). KIF20B is required for proper midbody organization and abscission in polarized cortical stem cells. It plays a role in the regulation of neuronal polarization by mediating the transport of specific cargos. KIF20B participates in the mobilization of SHTN1 and in the accumulation of PIP3 in the growth cone of primary hippocampal neurons in a tubulin and actin-dependent manner. In the developing telencephalon, KIF20B cooperates with SHTN1 to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. It is involved in cerebral cortex growth (By similarity). KIF20B acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed:17409436). [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q96Q89].