JARID1A/RBP2 is a member of the jumonji (jmj) domain containing gene family of histone demethylases that plays a role in chromatin regulation and influences transcriptional activation and suppression. Some recently characterized members of the jmj family include JARID1A/RBP2, JARID1C, JMJD1A, JMJD1B, JMJD1C, JMJD2A, JMJD2C and JMJD2D. JARID1A/RBP2 functions to specifically demethylate lys-4 of histone 3 and interacts with the tumor suppressor protein pRb. Alternate names for JARID1a/RBP2 include jumonji/ARID domain-containing protein 1A, retinoblastoma-binding protein 2, RBBP-2, RBBP2, and RBP2.
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