Rabbit anti-RPA70 IHC Antibody
Catalog #
RPA70
Human
,Mouse
IHC
Rabbit
Polyclonal
Whole IgG
Between 350 and 400
IgG
Unconjugated
Antigen Affinity Purified
Product Details
Mouse,
Human
Rabbit,
Monkey
Human
2 - 8 °C
1 year from date of receipt
Replication protein A (RPA) is a multisubunit complex that carries out DNA mismatch repair (MMR) in association with MSH2 (a subunit of human MutS heterodimers), MLH1 (a subunit of human MutL heterodimers), PCNA, and DNA polymerase-delta. RPA is composed of a heterotrimer that includes subunits of 70 kDa (RPA1), 32kDa (RPA2), and 14kDa (RPA3). RPA1, the 70 kDa subunit, is an ssDNA binding protein that has been shown to be phosphorylated by ATM and ATR in response to DNA damage. In addition to a role in MMR, RPA also functions in the initiation of DNA replication and DNA unwinding at origins of replication.
Alternate Names
HSSB; MST075; MSTP075; REPA1; replication factor A protein 1; replication protein A 70 kDa DNA-binding subunit; replication protein A1, 70kDa; RF-A; RF-A protein 1; RP-A; RP-A p70; RPA70; single-stranded DNA-binding protein
Applications
