Rabbit anti-AKAP8/AKAP95 IHC Antibody
Catalog #
AKAP8/AKAP95
Human
,Mouse
IHC
Rabbit
Polyclonal
Whole IgG
Between 642 and C-term
IgG
Unconjugated
Antigen Affinity Purified
Product Details
Mouse,
Human
Bovine
Human
2 - 8 °C
1 year from date of receipt
AKAP8/AKAP95 has been characterized as a 95 kDa protein kinase A (PKA)-anchoring protein and regulatory subunit of PKA that functions to recruit the condensin complex for chromosome condensation during mitosis. A role in DNA replication has also been demonstrated through its interaction with the pre-replication complex component, MCM2 (mini-chromosome maintenance 2). Inhibition of AKAP8/AKAP95 association with MCM2 inhibits replication initiation and elongation in vitro. AKAP8/AKAP95 has also been shown to be involved in apoptosis. KAP8/AKAP95 associates with caspase 3 and serves as a carrier to transport caspase 3 from the cytoplasm to the nucleus to induce morphological changes in the nucleus.
Alternate Names
A kinase (PRKA) anchor protein 8; AKAP 95; AKAP-8; AKAP95; AKAP-95; A-kinase anchor protein 8; A-kinase anchor protein 95 kDa; A-kinase anchor protein, 95kDa
Applications
