Rabbit anti-Sin1 IHC Antibody
Catalog #
Sin1
Human
,Mouse
IHC
Rabbit
Polyclonal
Whole IgG
Between 470 and C-term
IgG
Unconjugated
Antigen Affinity Purified
Product Details
Mouse,
Human
Guinea_pig,
Horse,
Zebra_finch,
Turkey,
Sheep,
Monkey,
Dog,
Chicken,
Pig,
Bovine,
Rat
Human
2 - 8 °C
1 year from date of receipt
Stress-activated map kinase-interacting protein 1 (Sin1) is highly similar to the yeast stress- activated protein kinase SIN1. Sin1 is an essential mTORC2 subunit that is required to act as the PDK2 that phosphorylates Akt/PKB at Ser 473. Sin1 has been implicated as a scaffolding protein. Sin1 is required for rictor binding in the mTORC2 complex. Sin1 has also been shown to be important to the SAPK (stress-activated kinase) signaling pathway and in the nucleus may act as a scaffold between ATF-2 and p38 to facilitate p38-induced phosphorylation of ATF-2. Sin1 is also found to form a complex with c-Jun N-terminal kinase (JNK) and may similarly function as a scaffolding protein in JNK signaling.
Target of rapamycin complex 2 subunit MAPKAP1
Alternate Names
JC310; MEKK2-interacting protein 1; MIP1; mitogen-activated protein kinase 2-associated protein 1; mSIN1; ras inhibitor MGC2745; SAPK-interacting protein 1; SIN1; SIN1b; SIN1g; stress-activated map kinase interacting protein 1; Stress-activated map kinase-interacting protein 1; stress-activated protein kinase-interacting 1; target of rapamycin complex 2 subunit MAPKAP1; TORC2 subunit MAPKAP1
Applications
