Rabbit anti-RCC2 IHC Antibody
Catalog #
RCC2
Human
,Mouse
IHC
Rabbit
Polyclonal
Whole IgG
Between 475 and C-term
IgG
Unconjugated
Antigen Affinity Purified
Product Details
Mouse,
Human
Horse,
Monkey,
Dog,
Pig
Human
2 - 8 °C
1 year from date of receipt
RCC2 (regulator of chromosome condensation 2) is a member of the RCC1 family of guanine nucleotide exchange factors. RCC2 has been identified as part of the chromosomal passenger complex (CPC) which coordinates the chromosomal and cytoskeletal events of mitosis. Chromosomal passengers are proteins present in complexes with aurora B, inner centromeric protein (INCENP), survivin, and borealin. RCC2 has been demonstrated to be required for the recruitment of survivin and aurora B and is essential for proper chromosome segregation and the completion of cell cleavage. Loss of RCC2 inhibits spindle assembly, activates the spindle assembly checkpoint, and blocks cells in prometaphase.
Alternate Names
epididymis secretory sperm binding protein; protein RCC2; RCC1-like protein TD-60; TD-60; telophase disk protein of 60 kDa
Applications