Rabbit anti-RNF20 IHC Antibody
Catalog #
RNF20
Human
IHC
Rabbit
Polyclonal
Whole IgG
Between 125 and 175
IgG
Unconjugated
Antigen Affinity Purified
Product Details
Human
Guinea_pig,
Mouse,
Horse,
Zebra_finch,
Monkey,
Dog,
Chicken,
Pig,
Rabbit,
Bovine,
Rat
Human
2 - 8 °C
1 year from date of receipt
The conjugation of ubiquitin to proteins is an important means to regulate protein activity for many cellular processes. Targeting of proteins by ubiquitination occurs in three main steps that involve the activation of ubiquitin by E1 enzymes, the carrying of ubiquitin to the target protein by E2 enzymes, and the ligation of ubiquitin to the target protein by E3 enzymes. Ring finger protein 20 (RNF20) is a member of the RING type E3 ubiquitin ligases. RNF20 forms a complex with RNF40 to carry out H2B monoubiquitination in association with hPAF and the UbcH6 ubiquitin E2-conjugating enzyme. H2B monoubiquitination by RNF40/RNF20 has been shown to be associated with increased H3 methylation and gene transcription.
Alternate Names
BRE1; BRE1 E3 ubiquitin ligase homolog; BRE1A; BRE1-A; E3 ubiquitin-protein ligase BRE1A; hBRE1; homolog of S. cerevisiae BRE1; RING finger protein 20; RING-type E3 ubiquitin transferase BRE1A
Applications
