Rabbit anti-TAFII68 IHC Antibody
Catalog #
TAFII68
Human
IHC
Rabbit
Polyclonal
Whole IgG
Between 200 and 250
IgG
Unconjugated
Antigen Affinity Purified
Product Details
Human
Human
2 - 8 °C
1 year from date of receipt
The TFIID complex is important for coordinating the pre-initiation complex and transcription by RNA Pol II. The complex contains the TFIID protein, TATA binding protein (TBP) and multiple TBP-associated factors (TAFs). TAFII68 was identified as a subunit of the TFIID complex, but has also been found to be associated with the Pol II multiprotein complex. TAFII68 is part of the TET family of proteins that can bind RNA and single-stranded DNA. This family also includes the human sarcoma-associated proteins EWS and TLS. The association of this family of proteins with Pol II suggests that they may bridge the processes of transcription initiation and elongation. The N-terminus domain of TAFII68 in gene fusions has been shown to have oncogenic properties, similar to the chromosomal translocation associated with the EWS gene.
TATA-binding protein-associated factor 2N
Alternate Names
68 kDa TATA-binding protein-associated factor; Npl3; RBP56; RBP56/CSMF fusion; RNA-binding protein 56; TAF(II)68; TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa; TAF2N; TAFII68; TATA box binding protein (TBP)-associated factor, RNA polymerase II, N, 68kD (RNA-binding protein 56); TATA box-binding protein-associated factor 2N (RNA-binding protein 56); TATA-binding protein-associated factor 2N; TBP-associated factor 15
Applications
