PCNA IHC Antibody

Rabbit anti-PCNA IHC Antibody, Affinity Purified
IHC-00012
$360.00 Request Bulk Quote
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Secondary Antibodies
PCNA IHC AntibodyPCNA IHC AntibodyPCNA IHC AntibodyPCNA IHC Antibody
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  • PCNA IHC Antibody
  • PCNA IHC Antibody
  • PCNA IHC Antibody
  • PCNA IHC Antibody
Quantity:
0.1 ml (50 - 250 slides)
Reactivity:
Human, Mouse
100% Sequence Identity:
Format:
Whole IgG
Applications:
GeneID URL:
ProteinID URL:
Alternative Names:
Cyclin, cyclin, Proliferating cell nuclear antigen, proliferating cell nuclear antigen, DNA polymerase delta auxiliary protein
Host:
Rabbit
Antibody Type:
Polyclonal
Purity:
Antigen Affinity Purified
Conjugate:
Unconjugated
Physical State:
Liquid
PCNA (Proliferating Cell Nuclear Antigen) was first identified as a factor expressed in the nuclei of replicating cells. PCNA plays a role in both DNA synthesis and repair. PCNA functions as a processivity factor for DNA polymerase by acting as a DNA clamp that tethers the polymerase catalytic units to the DNA template. The structure of PCNA is that of a trimeric ring that encircles and slides along replicating DNA. PCNA interacts with and is regulated by several proteins involved in cell cycle control and check point processes.
  • Deniset JF et al., Chlamydophila pneumoniae infection leads to smooth muscle cell proliferation and thickening in the coronary artery without contributions from a host immune response. Am J Pathol. 2010 Feb;176(2):1028-37. WB, IHC-P
  • Psyrri A et al., Correlates and determinants of nuclear epidermal growth factor receptor content in an oropharyngeal cancer tissue microarray. Cancer Epidemiol Biomarkers Prev. 2008 Jun;17(6):1486-92.
  • Tripathi P et al., Absence of canonical Smad signaling in ureteral and bladder mesenchyme causes ureteropelvic junction obstruction. J Am Soc Nephrol. 2012 Apr;23(4):618-28. IHC-P
  • Tripathi P et al., Activation of NFAT signaling establishes a tumorigenic microenvironment through cell autonomous and non-cell autonomous mechanisms. Oncogene. 2013 Apr 29. doi: 10.1038/onc.2013.132. IHC-P
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