Rabbit anti-EPC1 Antibody
Catalog #
EPC1
Human
IP
,WB
Rabbit
Polyclonal
Whole IgG
between 325 and 375
IgG
Unconjugated
Antigen Affinity Purified
Product Details
Human
Mouse
Human
2 - 8 °C
1 year from date of receipt
Enhancer of polycomb homolog 1 (EPC1) is a component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9H2F5].
Alternate Names
enhancer of polycomb homolog 1; Epl1
Applications