Rabbit anti-SMARCD1/BAF60a Antibody
Catalog #
SMARCD1/BAF60a
Human
,Mouse
WB
Rabbit
Polyclonal
Whole IgG
between 250 and 300
IgG
Unconjugated
Antigen Affinity Purified
Product Details
Human,
Mouse
Bovine
Human
2 - 8 °C
1 year from date of receipt
The SMARCs (SWI/SNF-related, matrix-associated, actin-dependent regulators of chromatin), and BAFs (BRG1-associated factors), have been identified as components of the mammalian SWI/SNF-like chromatin-remodeling protein complexes. These multi-protein complexes are proposed to function as ATP-driven motors that translocate along DNA and destabilize nucleosomal structures to facilitate transcription factor binding. SMARCD1/BAF60a is subunit of the SWI/SNF complex that has been identified as a factor that interacts with nuclear receptors such as the vitamin D receptor and glucocorticoid receptor and a subset of Fos/Jun dimers. SMARCD1 has also been shown to interact with p53 and is suggested to be involved in the tumor suppressor activity of p53. From these findings it has been concluded that SMARCD1 functions as a direct link between transcription factors and SWI/SNF remodeling activity to regulate transcription.
SMARCD1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1
Alternate Names
60 kDa BRG-1/Brm-associated factor subunit A; BAF60A; BRG1-associated factor 60A; chromatin remodeling complex BAF60A subunit; CRACD1; mammalian chromatin remodeling complex BRG1-associated factor 60A; Rsc6p; SWI/SNF complex 60 kDa subunit; SWI/SNF complex 60 kDa subunit A; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1; Swp73-like protein
Applications
