Rabbit anti-SMG1 Antibody
Catalog #
SMG1
Human
WB
Rabbit
Polyclonal
Whole IgG
between 1250 and 1300
IgG
Unconjugated
Antigen Affinity Purified
Product Details
Human
Mouse
Human
2 - 8 °C
1 year from date of receipt
SMG1 is a PIKK (phosphoinositide 3-kinase related kinases) protein kinase that plays a key role in RNA surveillance via nonsense-mediated mRNA decay (NMD). SMG1 phosphorylates Upf1, a factor that possesses RNA helicase activity and is also central to NMD. SMG1 and UPF-1 have been shown to exist in a complex with the translation termination release factors eRF3, and eRF1. This complex has been termed SURF and associates with the exon junction complex (EJC) to function in the recognition of premature termination codons in aberrant RNAs to trigger NMD.
Serine/threonine-protein kinase SMG1
Alternate Names
61E3.4; ATX; hSMG-1; lambda/iota protein kinase C-interacting protein; lambda-interacting protein; LIP; PI-3-kinase-related kinase SMG-1; serine/threonine-protein kinase SMG1; SMG-1; smg-1 homolog, phosphatidylinositol 3-kinase-related kinase; SMG1 phosphatidylinositol 3-kinase-related kinase
Applications