COP1/RFWD2 Antibody

Rabbit anti-COP1/RFWD2 Antibody, Affinity Purified
A300-894A
$314.00 Request Bulk Quote
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Secondary Antibodies
COP1/RFWD2 Antibody
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Quantity:
0.1 ml (20 - 100 blots)
Reactivity:
Human, Mouse
100% Sequence Identity:
Format:
Whole IgG
Applications:
GeneID URL:
ProteinID URL:
Alternative Names:
hCOP1, RFWD2, RNF200, RP11-318C24.3, hCOP1, E3 ubiquitin-protein ligase RFWD2, Constitutive photomorphogenesis protein 1 homolog, RING finger and WD repeat domain protein 2, RING finger protein 200, ring finger and WD repeat domain 2, E3 ubiquiti
Host:
Rabbit
Antibody Type:
Polyclonal
Purity:
Antigen Affinity Purified
Conjugate:
Unconjugated
Physical State:
Liquid
Constitutive photomorphogenic protein 1 (COP1) has been characterized in plants as a RING-finger-containing protein that functions to repress plant photomorphogenesis. In mammals, COP1 has been identified as an E3 ubiquitin ligase that negatively regulates p53 protein levels in unstressed cells. In response to DNA damage COP1 is phosphorylated by the ataxia telangiectasia mutated (ATM) protein kinase and is rapidly degraded releasing p53 to exert its tumor suppressor activities.
  • Fazekas B et al., UVB-dependent changes in the expression of fast-responding early genes is modulated by huCOP1 in keratinocytes J Photochem Photobiol B. 2014 Aug 9;140C:215-222.  ICC, IF
  • Horikawa I et al., Autophagic degradation of the inhibitory p53 isoform Δ133p53α as a regulatory mechanism for p53-mediated senescence Nat Commun. 2014 Aug 21;5:4706.  WB
  • Li DQ et al., E3 ubiquitin ligase COP1 regulates the stability and functions of MTA1. Proc Natl Acad Sci U S A. 2009 Oct 13;106(41):17493-8. WB
  • Li DQ et al., MTA1 coregulator regulates p53 stability and function. J Biol Chem. 2009 Dec 11;284(50):34545-52. WB
  • Lu G et al., Phosphorylation of ETS1 by Src Family Kinases Prevents Its Recognition by the COP1 Tumor Suppressor. Cancer Cell. 2014 Aug 11;26(2):222-34. WB, IP
  • Shao J et al., COP1 and GSK3β Cooperate to Promote c-Jun Degradation and Inhibit Breast Cancer Cell Tumorigenesis Neoplasia. 2013 Sep;15(9):1075-85. WB
  • Su CH et al., 14-3-3sigma exerts tumor-suppressor activity mediated by regulation of COP1 stability. Cancer Res. 2011 Feb 1;71(3):884-94. IHC-P, WB
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