SRA Antibody

Rabbit anti-SRA Antibody, Affinity Purified
A300-743A
$314.00 Request Bulk Quote
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Secondary Antibodies
SRA Antibody
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Quantity:
0.1 ml (20 - 100 blots)
Reactivity:
Human
Format:
Whole IgG
Applications:
GeneID URL:
ProteinID URL:
Alternative Names:
SRAP, SRA1, PP7684, STRAA1, pp7684, Steroid receptor RNA activator 1, Steroid receptor RNA activator protein, steroid receptor RNA activator 1, steroid receptor coactivator, steroid receptor RNA activator protein, steroid receptor RNA activator
Host:
Rabbit
Antibody Type:
Polyclonal
Purity:
Antigen Affinity Purified
Conjugate:
Unconjugated
Physical State:
Liquid
Steroid receptor RNA activator 1 (SRA) was originally identified as a functional non-coding RNA that has been shown to be a coactivator of steroid receptors for androgens (AR), estrogens (ER), glucocorticoids, and progestins (PR). SRA exists in ribonucleoprotein complexes with steroid receptor coactivators (SRCs) and steroid receptors and may modulate transcriptional specificity. A 236 amino-acid protein encoded by an SRA-RNA isoform has also been identified. The SRA protein (SRAP) is widely expressed in breast cancer cell lines and breast cancer and has been demonstrated to modify the activity of the estrogen receptor.
  • Cooper C et al., Increasing the relative expression of endogenous non-coding Steroid Receptor RNA Activator (SRA) in human breast cancer cells using modified oligonucleotides. Nucleic Acids Res. 2009 Jul;37(13):4518-31. WB
  • Liu S et al., SRA Regulates Adipogenesis by Modulating p38/JNK Phosphorylation and Stimulating Insulin Receptor Gene Expression and Downstream Signaling. PLoS One. 2014 Apr 17;9(4):e95416. WB
  • Vicent GP et al., Unliganded progesterone receptor-mediated targeting of an RNA-containing repressive complex silences a subset of hormone-inducible genes. Genes Dev. 2013 May 15;27(10):1179-97 WB
  • Yan Y et al., Steroid receptor RNA activator protein (SRAP) expression as a prognostic factor in ER+ human breast tumors. J Cancer Res Clin Oncol. 2013 Aug 2. WB
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