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Primary Antibodies  

Rabbit anti-CRM1 Antibody

Bethyl Laboratories®
Bethyl Laboratories®

Catalog #

Validated
Citations (20)
Target:

CRM1

Reactivity:

Human

,

Mouse

Applications:

IHC

,

IP

,

WB

Host:

Rabbit

Clonality:

Polyclonal

Format:

Whole IgG

Immunogen:

between 1025 and C-term

Isotype:

IgG

Conjugate:

Unconjugated

Purity:

Antigen Affinity Purified

100 µl (1000 µg/ml)

10 µl (1000 µg/ml)

Product Details

Specifications
Verified Reactivity

Mouse,

Human

Antigen Species

Human

Concentration
1000 µg/ml
Storage

2 - 8 °C

Shelf Life

1 year from date of receipt

Physical State
Liquid
Buffer

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide


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Additional Product Information

Chromosome region maintenance 1 protein homolog (CRM1) is the Ran-GTP-binding nuclear export receptor for proteins bearing a leucine rich nuclear export signal and RNAs. CRM1 also possesses a mitotic function as it localizes to kinetochores, and with Ran-GTP, recruits Ran-GTPase-activating protein (Ran-GAP1) and Ran-binding protein (Ran-BP2) for proper mitotic spindle assembly and chromosome segregation. Additionally, CRM1 is suggested to function as a loading dock of various cell cycle and checkpoint factors such as cyclins, Cdks, p53 and BRCA1, to regulate proper chromosome duplication and genomic stability.

7514

XPO1

exportin 1

O14980

Exportin-1

Alternate Names

chromosome region maintenance 1 homolog; chromosome region maintenance 1 protein homolog; CRM1; emb; exp1; exportin 1 (CRM1 homolog, yeast); exportin-1; exportin-1 (required for chromosome region maintenance)

Applications

All western blot analysis is performed using 5% Milk-TBST for blocking and as antibody diluent. Primary antibody is incubated overnight.

Western blots of cell lysates are performed using Goat anti-Rabbit IgG Heavy and Light Chain Antibody (Cat. No. A120-101P).

Western blots of immunoprecipitates are performed using Goat anti-Rabbit Light Chain HRP Conjugate (Cat. No. A120-113P) with 5% Normal Pig Serum (Cat. No. S100-020) added to the blocking buffer.