DDX6 Antibody

Rabbit anti-DDX6 Antibody, Affinity Purified
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Secondary Antibodies
DDX6 AntibodyDDX6 Antibody
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  • DDX6 Antibody
  • DDX6 Antibody
0.1 ml (50 - 150 blots)
Human, Mouse
100% Sequence Identity:
Whole IgG
ProteinID URL:
Alternative Names:
Oncogene RCK, HLR2, P54, DEAD box-6, oncogene RCK, Probable ATP-dependent RNA helicase ATP-dependent RNA helicase p54, DEAD box protein 6, DEADAsp-Glu-Ala-Asp) box helicase 6, probable ATP-dependent RNA helicase DEADAsp-Glu-Ala-Asp) box polypep
Antibody Type:
Antigen Affinity Purified
Physical State:
DDX6 is a member of the DEAD box family of proteins that possesses several conserved motifs which include the highly conserved DEAD (Asp-Glu-Ala-Asp) amino acid sequence motif. The major activity of DEAD box proteins is to function as ATP-dependent RNA helicases. As helicases, DEAD proteins play an important role in all aspects of RNA metabolism and function which include pre-mRNA splicing, RNA synthesis, RNA degradation, RNA export, RNA translation, RNA secondary structure formation, ribosome biogenesis, and the assembly of RNP complexes. DDX6 has been observed to positively regulate growth by modulating gene expression at the translational level.
  • Ariumi Y et al., Hepatitis C virus hijacks P-body and stress granule components around lipid droplets. J Virol. 2011 Jul;85(14):6882-92. WB, ICC
  • Chahar HS et al., P-body components LSM1, GW182, DDX3, DDX6 and XRN1 are recruited to WNV replication sites and positively regulate viral replication. Virology. 2013 Feb 5;436(1):1-7. ICC
  • Chu CY et al., Translation repression in human cells by microRNA-induced gene silencing requires RCK/p54. PLoS Biol. 2006 Jul;4(7):e210. WB
  • Cougot N et al., Dendrites of mammalian neurons contain specialized P-body-like structures that respond to neuronal activation. J Neurosci. 2008 Dec 17;28(51):13793-804. ICC
  • Cougot N et al., The Dual Organization of P-bodies Revealed by Immunoelectron Microscopy and Electron Tomography. J Mol Biol. 2012 Jun 29;420(1-2):17-28. ICC
  • Crist CG et al., Muscle satellite cells are primed for myogenesis but maintain quiescence with sequestration of Myf5 mRNA targeted by microRNA-31 in mRNP granules. Cell Stem Cell. 2012 Jul 6;11(1):118-26.
  • Emara MM et al., Angiogenin-induced tRNA-derived stress-induced RNAs promote stress-induced stress granule assembly. J Biol Chem. 2010 Apr 2;285(14):10959-68. ICC
  • Ernoult-Lange M et al., Multiple binding of repressed mRNAs by the P-body protein Rck/p54. RNA. 2012 Sep;18(9):1702-15.
  • Ernoult-Lange M et al., Nucleocytoplasmic traffic of CPEB1 and accumulation in Crm1 nucleolar bodies. Mol Biol Cell. 2009 Jan;20(1):176-87. ICC
  • Huys A et al., Modulation of Hepatitis C Virus RNA Accumulation and Translation by DDX6 and miR-122 Are Mediated by Separate Mechanisms. PLoS One. 2013 Jun 24;8(6):e67437. WB
  • Jangra RK et al., DDX6 (Rck/p54) is required for efficient hepatitis C virus replication but not for internal ribosome entry site-directed translation. J Virol. 2010 Jul;84(13):6810-24. WB, ICC
  • Kamenska A et al., Human 4E-T represses translation of bound mRNAs and enhances microRNA-mediated silencing. Nucleic Acids Res. 2013 Dec 13.
  • Kemler I et al., Live-cell coimaging of the genomic RNAs and Gag proteins of two lentiviruses. J Virol. 2010 Jul;84(13):6352-66. ICC
  • Marin M et al., Human immunodeficiency virus type 1 Vif functionally interacts with diverse APOBEC3 cytidine deaminases and moves with them between cytoplasmic sites of mRNA metabolism. J Virol. 2008 Jan;82(2):987-98. ICC
  • Marnef A et al., Distinct functions of maternal and somatic Pat1 protein paralogs. RNA. 2010 Nov;16(11):2094-107. WB, ICC
  • Marnef A et al., RNA-related nuclear functions of human Pat1b, the P-body mRNA decay factor. Mol Biol Cell. 2012 Jan;23(1):213-24. ICC
  • Morris AR et al., Ribonomic analysis of human Pum1 reveals cis-trans conservation across species despite evolution of diverse mRNA target sets. Mol Cell Biol. 2008 Jun;28(12):4093-103. ICC
  • Novotny I et al., Nuclear LSm8 affects number of cytoplasmic P-bodies via controlling cellular distribution of LSm proteins. Mol Biol Cell. 2012 Oct;23(19):3776-85. ICC
  • Otsuka Y et al., Identification of a cytoplasmic complex that adds a cap onto 5'-monophosphate RNA. Mol Cell Biol. 2009 Apr;29(8):2155-67. ICC
  • Pager CT et al., Modulation of hepatitis C virus RNA abundance and virus release by dispersion of processing bodies andenrichment of stress granules. Virology. 2013 Jan 20;435(2):472-84. WB
  • Saito K et al., MicroRNA 130 family regulates the hypoxia response signal through the P-body protein DDX6. Nucleic Acids Res. 2011 Aug;39(14):6086-99. WB, ICC
  • Savas JN et al., A role for huntington disease protein in dendritic RNA granules. J Biol Chem. 2010 Apr 23;285(17):13142-53. ICC
  • Song MG et al., 3' Terminal oligo U-tract-mediated stimulation of decapping. RNA. 2007 Dec;13(12):2356-65. WB
  • Souquere S et al., Unravelling the ultrastructure of stress granules and associated P-bodies in human cells. J Cell Sci. 2009 Oct 15;122(Pt 20):3619-26. ICC
  • Taddeo B et al., The virion-packaged endoribonuclease of herpes simplex virus 1 cleaves mRNA in polyribosomes. Proc Natl Acad Sci U S A. 2009 Jul 21;106(29):12139-44. ICC
  • Totaro A et al., The human Pat1b protein: a novel mRNA deadenylation factor identified by a new immunoprecipitation technique. Nucleic Acids Res. 2011 Jan;39(2):635-47. WB
  • Wichroski MJ et al., Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies. PLoS Pathog. 2006 May;2(5):e41. WB
  • Zhai Y et al., Coordinated changes in mRNA turnover, translation, and RNA processing bodies in bronchial epithelial cells following inflammatory stimulation. Mol Cell Biol. 2008 Dec;28(24):7414-26. WB
  • Zheng D et al., Deadenylation is prerequisite for P-body formation and mRNA decay in mammalian cells. J Cell Biol. 2008 Jul 14;182(1):89-101. WB
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