SMG1 Antibody

Rabbit anti-SMG1 Antibody, Affinity Purified
A300-393A
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Secondary Antibodies
SMG1 Antibody
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Quantity:
0.1 ml (10 - 100 blots)
Reactivity:
Human
100% Sequence Identity:
Format:
Whole IgG
Applications:
GeneID URL:
ProteinID URL:
Alternative Names:
61E3.4, ATX, KIAA0421, LIP, Serine/threonine-protein kinase Lambda/iota protein kinase C-interacting protein, Lambda-interacting protein, SMG1 phosphatidylinositol 3-kinase-related kinase, serine/threonine-protein kinase lambda-interacting prote
Host:
Rabbit
Antibody Type:
Polyclonal
Purity:
Antigen Affinity Purified
Conjugate:
Unconjugated
Physical State:
Liquid
SMG1 is a PIKK (phosphoinositide 3-kinase related kinases) protein kinase that plays a key role in RNA surveillance via nonsense-mediated mRNA decay (NMD). SMG1 phosphorylates Upf1, a factor that possesses RNA helicase activity and is also central to NMD. SMG1 and UPF-1 have been shown to exist in a complex with the translation termination release factors eRF3, and eRF1. This complex has been termed SURF and associates with the exon junction complex (EJC) to function in the recognition of premature termination codons in aberrant RNAs to trigger NMD.
  • Kaizuka T et al., Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly. J Biol Chem. 2010 Jun 25;285(26):20109-16. WB
  • Kang TH et al., Circadian oscillation of nucleotide excision repair in mammalian brain. Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2864-7. WB
  • McIlwain DR et al., Smg1 is required for embryogenesis and regulates diverse genes via alternative splicing coupled to nonsense-mediated mRNA decay. Proc Natl Acad Sci U S A. 2010 Jul 6;107(27):12186-91. WB
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