Pirh2 Antibody

Description

Rabbit anti-Pirh2 Antibody, Affinity Purified

Catalog No.A300-357A

Price$314.00 Request Bulk Quote

Data Sheet

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Secondary Antibodies

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Product Information
Background
Related Products
Citations
Ordering Information

Quantity:

0.1 ml (10 - 100 blots)

Reactivity:

Human

100% Sequence Identity:

Orangutan, Rhesus Monkey, Gorilla, Northern white-cheeked... more...

Format:

Whole IgG

Applications:

WB, IP

GeneID URL:

25898

ProteinID URL:

NP_05625.1

Alternative Names:

p53 induced RING-H2 antibody, ZNF363 antibody, Zinc Finger Protein 363 antibody, CHIMP antibody, CH-rich interacting match with PLAG1 antibody, hARNIP antibody, human androgen receptor N-terminal-interacting protein antibody, PRO1996 antibody, DKFZp586C1620 antibody

Host:

Rabbit

Antibody Type:

Polyclonal

Purity:

Antigen Affinity Purified

Conjugate:

Unconjugated

Physical State:

Liquid

Pirh2 has been demonstrated to function as an ubiquitin ligase that targets p53 for proteasome-mediated degradation. Pirh2 is also an androgen receptor (AR)-interacting protein and modulates the transcriptional activity of AR by regulating the levels of the AR corepressor, HDAC1, via ubiquitination.

SubType	Description	Catalog No.
PRIMARY ANTIBODIES	Rabbit anti-COP1/RFWD2 Antibody, Affinity Purified	A300-896A
PRIMARY ANTIBODIES	Rabbit anti-COP1/RFWD2 Antibody, Affinity Purified	A300-894A
PRIMARY ANTIBODIES	Rabbit anti-COP1/RFWD2 Antibody, Affinity Purified	A300-895A

Bohgaki M et al., The E3 ligase PIRH2 polyubiquitylates CHK2 and regulates its turnover. Cell Death Differ. 2013 Mar 1. doi: 10.1038/cdd.2013.7. WB
PubMed: 23449389
Corcoran CA et al., Identification and characterization of two novel isoforms of Pirh2 ubiquitin ligase that negatively regulate p53 independent of RING finger domains. J Biol Chem. 2009 Aug 14;284(33):21955-70. WB
PubMed: 19483087
Duan S et al., Phosphorylation of Pirh2 by calmodulin-dependent kinase II impairs its ability to ubiquitinate p53. EMBO J. 2007 Jul 11;26(13):3062-74. WB, ICC
PubMed: 17568776
Duan S et al., The Pirh2-keratin 8/18 interaction modulates the cellular distribution of mitochondria and UV-induced apoptosis. Cell Death Differ. 2009 Jun;16(6):826-37.
PubMed: 19282868
Duan W et al., Differential response between the p53 ubiquitin-protein ligases Pirh2 and MdM2 following DNA damage in human cancer cells. Exp Cell Res. 2006 Oct 15;312(17):3370-8. WB
PubMed: 16934800
Duan W et al., Expression of Pirh2, a newly identified ubiquitin protein ligase, in lung cancer. J Natl Cancer Inst. 2004 Nov 17;96(22):1718-21.
PubMed: 15547185
Han C et al., Endoplasmic reticulum stress inhibits cell cycle progression via induction of p27 in melanoma cells.Cell Signal. 2012 Sep 23;25(1):144-149. IP
PubMed: 23010535
Jung YS et al., Pirh2 E3 Ubiquitin Ligase Modulates Keratinocyte Differentiation through p63. J Invest Dermatol. 2012 Dec 13. WB
PubMed: 23235527
Koivusalo R et al., Activation of p53 in cervical cancer cells by human papillomavirus E6 RNA interference is transient, but can be sustained by inhibiting endogenous nuclear export-dependent p53 antagonists. Cancer Res. 2006 Dec 15;66(24):11817-24. WB
PubMed: 17178878
Sheng Y et al., Molecular basis of Pirh2-mediated p53 ubiquitylation. Nat Struct Mol Biol. 2008 Dec;15(12):1334-42.
PubMed: 19043414
Sion-Vardy N et al., p27kip1 Expression in non-small cell lung cancer is not an independent prognostic factor. Anticancer Res. 2010 Sep;30(9):3699-704. IHC-P
PubMed: 20944156
Yoneda-Kato N et al., Myeloid leukemia factor 1 regulates p53 by suppressing COP1 via COP9 signalosome subunit 3. EMBO J. 2005 May 4;24(9):1739-49. WB
PubMed: 15861129
Yurugi H et al., Prohibitins function as endogenous ligands for Siglec-9 and negatively regulate TCR signaling upon ligation. Biochem Biophys Res Commun. 2013 Apr 6. pii: S0006-291X(13)00549-4. doi: 10.1016/j.bbrc.2013.03.085. WB
PubMed: 23567969

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