gamma-H2AX Antibody

Rabbit anti-gamma-H2AX Antibody, Affinity Purified
A300-081A
$335.00 Request Bulk Quote
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Secondary AntibodiesPositive Controls
gamma-H2AX Antibodygamma-H2AX Antibody
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  • gamma-H2AX Antibody
  • gamma-H2AX Antibody
Quantity:
0.1 ml (50 - 150 blots)
Reactivity:
Human, Mouse
100% Sequence Identity:
Format:
Whole IgG
Applications:
GeneID URL:
ProteinID URL:
Alternative Names:
histone H2A.x antibody, H2a/x antibody
Host:
Rabbit
Antibody Type:
Polyclonal
Purity:
Antigen Affinity Purified
Conjugate:
Unconjugated
Physical State:
Liquid
H2AX is a member of the histone H2A family. The four core histones involved in the formation of the nucleosome structure of compacted chromatin are H2A, H2B, H3, and H4. H2AX may function to facilitate DNA repair, and recent studies have shown that H2AX is required for the maintenance of genomic stability. Gamma H2AX is the phosphorylated form of H2AX that results in response to DNA damage.
  • Bentle MS et al., Calcium-dependent modulation of poly(ADP-ribose) polymerase-1 alters cellular metabolism and DNA repair. J Biol Chem. 2006 Nov 3;281(44):33684-96. WB, ICC
  • Brouwer AK et al., Telomeric DNA mediates de novo PML body formation. Mol Biol Cell. 2009 Nov;20(22):4804-15. ICC
  • Buonomo SB et al., Mammalian Rif1 contributes to replication stress survival and homology-directed repair. J Cell Biol. 2009 Nov 2;187(3):385-98. WB
  • Burns MB et al., APOBEC3B is an enzymatic source of mutation in breast cancer. Nature. 2013 Feb 6. FACS
  • Caddle LB et al., Homologous recombination is necessary for normal lymphocyte development. Mol Cell Biol. 2008 Apr;28(7):2295-303. ICC
  • Chan YW et al., The kinetics of p53 activation versus cyclin E accumulation underlies the relationship between the spindle-assembly checkpoint and the postmitotic checkpoint. J Biol Chem. 2008 Jun 6;283(23):15716-23. WB
  • De Nicolo A et al., Multimodal assessment of protein functional deficiency supports pathogenicity of BRCA1 p.V1688del. Cancer Res. 2009 Sep 1;69(17):7030-7. WB
  • Eliezer Y et al., The direct interaction between 53BP1 and MDC1 is required for the recruitment of 53BP1 to sites of damage. J Biol Chem. 2009 Jan 2;284(1):426-35. WB, ICC
  • Ewald B et al., ATM and the Mre11-Rad50-Nbs1 complex respond to nucleoside analogue-induced stalled replication forks and contribute to drug resistance. Cancer Res. 2008 Oct 1;68(19):7947-55. WB, ICC
  • Gwak HS et al., Silencing of MicroRNA-21 Confers Radio-Sensitivity through Inhibition of the PI3K/AKT Pathway and Enhancing Autophagy in Malignant Glioma Cell Lines. PLoS One. 2012;7(10):e47449. ICC
  • Hamidi T et al., A novel Nupr1-Aurora kinase A pathway provides protection against metabolic stress-mediated autophagic-associated cell death. Clin Cancer Res. 2012 Oct 1;18(19):5234-46 IHC-P
  • Hau PM et al., Polyploidization increases the sensitivity to DNA-damaging agents in mammalian cells. FEBS Lett. 2006 Aug 21;580(19):4727-36. ICC
  • Ho CC et al., Stalled replication induces p53 accumulation through distinct mechanisms from DNA damage checkpoint pathways. Cancer Res. 2006 Feb 15;66(4):2233-41. WB
  • Igoucheva O et al., Differential cellular responses to exogenous DNA in mammalian cells and its effect on oligonucleotide-directed gene modification. Gene Ther. 2006 Feb;13(3):266-75. WB
  • Jiang G et al., Replication-mediated disassociation of replication protein A-XPA complex upon DNA damage: implications for RPA handing off. Cell Biol Int. 2012 Aug 1;36(8):713-20. WB
  • Kelsall IR et al., The Fanconi anaemia components UBE2T and FANCM are functionally linked to nucleotide excision repair. PLoS One. 2012;7(5):e36970. WB
  • Konstantinidou G et al., Dual phosphoinositide 3-kinase/mammalian target of rapamycin blockade is an effective radiosensitizing strategy for the treatment of non-small cell lung cancer harboring K-RAS mutations. Cancer Res. 2009 Oct 1;69(19):7644-52. WB
  • Li Y et al., Chemopreventive agent 3,3'-diindolylmethane selectively induces proteasomal degradation of class I histone deacetylases. Cancer Res. 2010 Jan 15;70(2):646-54. WB
  • Liu Y et al., DNA damage responses in progeroid syndromes arise from defective maturation of prelamin A. J Cell Sci. 2006 Nov 15;119(Pt 22):4644-9. WB
  • Matsuoka S et al., ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science. 2007 May 25;316(5828):1160-6. IP
  • Nichols GJ et al., Widespread phosphorylation of histone H2AX by species C adenovirus infection requires viral DNA replication. J Virol. 2009 Jun;83(12):5987-98. WB
  • Ordinario EC et al., Temporal regulation of Ig gene diversification revealed by single-cell imaging. J Immunol. 2009 Oct 1;183(7):4545-53. ICC
  • Pereg Y et al., Differential roles of ATM- and Chk2-mediated phosphorylations of Hdmx in response to DNA damage. Mol Cell Biol. 2006 Sep;26(18):6819-31. WB, ICC
  • Rai P et al., Continuous elimination of oxidized nucleotides is necessary to prevent rapid onset of cellular senescence. Proc Natl Acad Sci U S A. 2009 Jan 6;106(1):169-74. ICC
  • Rainey MD et al., Transient inhibition of ATM kinase is sufficient to enhance cellular sensitivity to ionizing radiation. Cancer Res. 2008 Sep 15;68(18):7466-74. WB
  • Salsman J et al., Proteomic profiling of the human cytomegalovirus UL35 gene products reveals a role for UL35 in the DNA repair response. J Virol. 2012 Jan;86(2):806-20. WB, ICC
  • Sankar N et al., c-Myc-induced aberrant DNA synthesis and activation of DNA damage response in p300 knockdown cells. J Biol Chem. 2009 May 29;284(22):15193-205.
  • Suzuki K et al., A novel and simple micro-irradiation technique for creating localized DNA double-strand breaks. Nucleic Acids Res. 2010 Jul;38(12):e129. ICC
  • Tomimatsu N et al., Distinct roles of ATR and DNA-PKcs in triggering DNA damage responses in ATM-deficient cells. EMBO Rep. 2009 Jun;10(6):629-35. WB, ICC
  • Tsang YH et al., Novel functions of the phosphatase SHP2 in the DNA replication and damage checkpoints. PLoS One. 2012;7(11):e49943. ICC

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