Phospho SMC1 (S966) Antibody

Rabbit anti-Phospho SMC1 (S966) Antibody, Affinity Purified
A300-050A
$335.00 Request Bulk Quote
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Secondary Antibodies
Phospho SMC1 (S966) AntibodyPhospho SMC1 (S966) AntibodyPhospho SMC1 (S966) Antibody
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  • Phospho SMC1 (S966) Antibody
  • Phospho SMC1 (S966) Antibody
  • Phospho SMC1 (S966) Antibody
Quantity:
0.1 ml (5 - 50 blots)
Reactivity:
Human
100% Sequence Identity:
Format:
Whole IgG
Applications:
GeneID URL:
ProteinID URL:
Alternative Names:
SMC1-alpha protein antibody, SMC1A antibody, DXS423E antibody, KIAA0178 antibody, SB1.8 antibody, SMC1L1 antibody, MGC138332 antibody, DKFZp686L19179 antibody
Host:
Rabbit
Antibody Type:
Polyclonal
Purity:
Antigen Affinity Purified
Conjugate:
Unconjugated
Physical State:
Liquid
Structural maintenance of chromosomes (SMC) proteins are part of the cohesin and condensin multisubunit complexes that play a critical role in chromosome organization, segregation, gene regulation, and DNA repair. The core cohesin complex includes a heterodimer of SMC1 and SMC3 that functions by forming a ring-like structure that holds sister chromatids together. Cohesin is important to sister chromatid separation and segregation during mitosis and meiosis and also plays a role in double-strand break repair by homologous recombination.
  • Austen B et al., Mutation status of the residual ATM allele is an important determinant of the cellular response to chemotherapy and survival in patients with chronic lymphocytic leukemia containing an 11q deletion. J Clin Oncol. 2007 Dec 1;25(34):5448-57 WB
  • Austen B et al., Mutations in the ATM gene lead to impaired overall and treatment-free survival that is independent of IGVH mutation status in patients with B-CLL. Blood. 2005 Nov 1;106(9):3175-82. WB
  • Badie S et al., RAD51C facilitates checkpoint signaling by promoting CHK2 phosphorylation. J Cell Biol. 2009 May 18;185(4):587-600. WB
  • Blackford AN et al., A role for E1B-AP5 in ATR signaling pathways during adenovirus infection. J Virol. 2008 Aug;82(15):7640-52. WB
  • Carlessi L et al., DNA-damage response, survival and differentiation in vitro of a human neural stem cell line in relation to ATM expression. Cell Death Differ. 2009 Jun;16(6):795-806. WB
  • Cheng WH et al., WRN is required for ATM activation and the S-phase checkpoint in response to interstrand cross-link-induced DNA double-strand breaks. Mol Biol Cell. 2008 Sep;19(9):3923-33. WB
  • d'Adda di Fagagna F et al., A DNA damage checkpoint response in telomere-initiated senescence. Nature. 2003 Nov 13;426(6963):194-8. ChIP
  • Delia D et al., MRE11 mutations and impaired ATM-dependent responses in an Italian family with ataxia-telangiectasia-like disorder. Hum Mol Genet. 2004 Sep 15;13(18):2155-63. WB
  • DiTullio RA Jr et al., 53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer. Nat Cell Biol. 2002 Dec;4(12):998-1002.
  • Ebi H et al., Novel NBS1 heterozygous germ line mutation causing MRE11-binding domain loss predisposes to common types of cancer. Cancer Res. 2007 Dec 1;67(23):11158-65. WB
  • Falck J et al., Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage. Nature. 2005 Mar 31;434(7033):605-11. WB
  • Goldberg M et al., MDC1 is required for the intra-S-phase DNA damage checkpoint. Nature. 2003 Feb 27;421(6926):952-6. WB
  • Heffernan TP et al., Cdc7-Dbf4 and the human S checkpoint response to UVC. J Biol Chem. 2007 Mar 30;282(13):9458-68. WB
  • Hickson I et al., Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM. Cancer Res. 2004 Dec 15;64(24):9152-9. WB
  • Hurov KE et al., A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability. Genes Dev. 2010 Sep 1;24(17):1939-50. WB
  • Jazayeri A et al., ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks. Nat Cell Biol. 2006 Jan;8(1):37-45. WB
  • Jowsey P et al., Characterisation of the sites of DNA damage-induced 53BP1 phosphorylation catalysed by ATM and ATR. DNA Repair (Amst). 2007 Oct 1;6(10):1536-44. WB
  • Jowsey PA et al., Human PTIP facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. J Biol Chem. 2004 Dec 31;279(53):55562-9. WB
  • Keimling M et al., Functional characterization connects individual patient mutations in ataxia telangiectasia mutated (ATM) with dysfunction of specific DNA double-strand break-repair signaling pathways. FASEB J. 2011 Nov;25(11):3849-60. WB
  • Kim BJ et al., Genome-wide reinforcement of cohesin binding at pre-existing cohesin sites in response to ionizing radiation in human cells. J Biol Chem. 2010 Jul 23;285(30):22784-92. ChIP
  • Matsuoka S et al., ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science. 2007 May 25;316(5828):1160-6. IP
  • Musio A et al., SMC1 involvement in fragile site expression. Hum Mol Genet. 2005 Feb 15;14(4):525-33. WB
  • Olson E et al., The Mre11 complex mediates the S-phase checkpoint through an interaction with replication protein A. Mol Cell Biol. 2007 Sep;27(17):6053-67. WB
  • Olson E et al., The Mre11-Rad50-Nbs1 complex acts both upstream and downstream of ataxia telangiectasia mutated and Rad3-related protein (ATR) to regulate the S-phase checkpoint following UV treatment. J Biol Chem. 2007 Aug 3;282(31):22939-52. WB
  • Rai R et al., BRIT1 regulates early DNA damage response, chromosomal integrity, and cancer. Cancer Cell. 2006 Aug;10(2):145-57.
  • Roche KC et al., Regulation of ATR-dependent pathways by the FHA domain containing protein SNIP1. Oncogene. 2007 Jul 5;26(31):4523-30. WB
  • Rohaly G et al., Simian virus 40 activates ATR-Delta p53 signaling to override cell cycle and DNA replication control. J Virol. 2010 Oct;84(20):10727-47. WB
  • Rossi R et al., The dispersal of replication proteins after Etoposide treatment requires the cooperation of Nbs1 with the ataxia telangiectasia Rad3-related/Chk1 pathway. Cancer Res. 2006 Feb 1;66(3):1675-83. WB
  • So S et al., Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sites. J Cell Biol. 2009 Dec 28;187(7):977-90. WB
  • Spycher C et al., Constitutive phosphorylation of MDC1 physically links the MRE11-RAD50-NBS1 complex to damaged chromatin. J Cell Biol. 2008 Apr 21;181(2):227-40. WB
  • Stewart GS et al., RIDDLE immunodeficiency syndrome is linked to defects in 53BP1-mediated DNA damage signaling. Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):16910-5. WB
  • Stucki M et al., MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks. Cell. 2005 Dec 29;123(7):1213-26. ICC, WB
  • Tomimatsu N et al., Distinct roles of ATR and DNA-PKcs in triggering DNA damage responses in ATM-deficient cells. EMBO Rep. 2009 Jun;10(6):629-35. WB
  • Townsend K et al., Mediator of DNA damage checkpoint 1 (MDC1) regulates mitotic progression. J Biol Chem. 2009 Dec 4;284(49):33939-48. WB
  • Wakeman TP et al., ATR regulates hexavalent chromium-induced S-phase checkpoint through phosphorylation of SMC1. Mutat Res. 2006 Nov 7;610(1-2):14-20. WB
  • Wang Y et al., MSH2 and ATR form a signaling module and regulate two branches of the damage response to DNA methylation. Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15387-92. WB
  • Xie H et al., Carcinogenic lead chromate induces DNA double-strand breaks in human lung cells. Mutat Res. 2005 Oct 3;586(2):160-72. WB
  • Yazdi PT et al., SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint. Genes Dev. 2002 Mar 1;16(5):571-82. WB, IP
  • Yoshioka K et al., ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts. Mol Cell. 2006 May 19;22(4):501-10. WB, IP

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