Rabbit anti-ROCK2 Antibody
Catalog #
ROCK2
Human
IP
,WB
Rabbit
Polyclonal
Whole IgG
between 1320 and C-term
IgG
Unconjugated
Antigen Affinity Purified
Product Details
Human
Mouse,
Bovine,
Rat
Human
2 - 8 °C
1 year from date of receipt
Rho-associated protein kinase 2 (ROCK2), or Rho kinase alpha, is a serine-threonine protein kinase that plays an important role in cellular apoptosis, growth, cell motility and cell contraction. ROCK2 shares an overall 65% homology in amino acid sequence with ROCK1. The ROCK1 and ROCK2 isoforms are products of two separate genes. Both ROCK1 and ROCK2 are downstream targets of the Rho A small GTP-binding protein. As downstream effectors of RhoA, ROCK1 and ROCK2 mediate changes in the actin cytoskeleton via phosphorylation of target proteins such as the MBS subunit of MLCP, MLC, ERM proteins, protein LIM kinase and adducin.
Rho-associated protein kinase 2
Alternate Names
p164 ROCK-2; Rho kinase 2; rho-associated protein kinase 2; Rho-associated, coiled-coil-containing protein kinase 2; rho-associated, coiled-coil-containing protein kinase II; ROCK-II
Applications