p600 Antibody

p600 is an E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. It recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, p600 forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Additionally p600 regulates integrin-mediated signaling and may play a role in activation of FAK in response to cell-matrix interactions [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q5T4S7].

Alternative names for p600 Antibody include UBR4 antibody, N-recognin-4 antibody, zinc-finger UBR1-type protein 1 antibody, retinoblastoma-associated factor of 600 kDa antibody, RBAF600 antibody.