p600 is an E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. It recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, p600 forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Additionally p600 regulates integrin-mediated signaling and may play a role in activation of FAK in response to cell-matrix interactions [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q5T4S7].
Alternative names for
p600 Antibody include N-recognin-4 antibody,
E3 ubiquitin-protein ligase UBR4 antibody,
600 kDa retinoblastoma protein-associated factor antibody,
Retinoblastoma-associated factor of 600 kDa antibody,
Zinc finger UBR1-type protein 1 antibody,
ubiquitin protein ligase E3 component n-recognin 4 antibody,
zinc finger UBR1-type protein 1 antibody,
retinoblastoma-associated factor of 600 kDa antibody,
retinoblastoma-associated factor 600-like protein antibody.