p53 Antibody

p53 is a tumor suppressor protein that is mutated or inactivated in over 50% of human cancers. Loss of function defects in p53 are the cause of the autosomal dominant familial cancer syndrome, Li-Fraumeni syndrome (LFS) that is characterized by the development of a diverse set of malignancies at very early ages. At the cellular level p53 is involved in the negative regulation of cell the cycle via its transactivational control of genes required for cell cycle progression. Depending on the physiological circumstance, p53 can promote growth arrest or apoptosis.

Alternative names for p53 Antibody include cellular tumor antigen p53 antibody, tumor suppressor p53 antibody, phosphoprotein p53 antibody, antigen NY-CO-13 antibody, TP53 antibody, TRP53 antibody, Li-Fraumeni syndrome antibody.