p16INK4a is a negative regulator of CDK4 and CDK6 kinase activity and cell cycle progression. P16INK4a regulates the cell cycle by inhibiting cyclin/CDK complex formation and the phosphorylation of the retinoblastoma protein (pRb). P16INK4a is a tumor suppressor associated with malignancies such as melanoma and astrocytoma and is the cause of Li-Fraumeni syndrome.
Alternative names for
p16INK4a Antibody include cyclin-dependent kinase 4 inhibitor A antibody, CKD4I antibody, p16-INK4 antibody, multiple tumor suppressor 1 antibody, MTS1 antibody, CDKN2A antibody, CDKN2 antibody.