cAbl Antibody

c-Abl is the human cellular homolog of a the v-Abl viral oncogene. v-Abl was originally discovered as a mouse cell-derived sequence in the genome of the Abelson murine leukemia virus (A-MuLV), a transforming retrovirus isolated by the laboratory of Dr. H.T. Abelson. c-Abl is a tyrosine kinase from the Src-family of tyrosine kinases that localizes to both the cytoplasm and nucleus. It bears an SH2 (src-homology 2) and SH3 (src-homology 3) domain responsible for mediating c-Abl protein-protein interactions. c-Abl is implicated to play a role in multiple cellular processes such as cell cycle checkpoint signaling, apoptosis, cell differentiation, cell adhesion, and transcriptional regulation. Chromosomal translocations involving the c-Abl gene are associated with human leukemias.
    Product Specifications
    Catalog # Size Price
    cAbl AntibodyReactivity: Human
    Applications: WB, IP, IHC-P, ICC, IF, PLA
    Immunogen: Between 550 and 600
    A301-660A100 µl (0.2 mg/ml) $339Add to Cart
    A301-660A-M100 µl (10 blots) $229Add to Cart
    A301-660A-T20 µl (2 blots) $50Add to Cart
    cAbl AntibodyReactivity: Human
    Applications: IP, IHC-P, ICC, IF, PLA
    Immunogen: Between 850 and 900
    A301-661A100 µl (1 mg/ml) $339Add to Cart
    A301-661A-T10 µl (1 mg/ml) $50Add to Cart

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