c-Cbl Antibody

The cbl oncogene was first identified as part of a transforming retrovirus which induces mouse pre-B and pro-B cell lymphomas. As an adaptor protein for receptor protein-tyrosine kinases, it positively regulates receptor protein-tyrosine kinase ubiquitination in a manner dependent upon its variant SH2 and RING finger domains. Ubiquitination of receptor protein-tyrosine kinases terminates signaling by marking active receptors for degradation [taken from NCBI GeneID:867].

Alternative names for c-Cbl Antibody include Casitas B-lineage lymphoma proto-oncogene antibody, Cas-Br-M ectropic retroviral transforming sequence antibody, RING finger protein 55 antibody, proto-oncogene c-CBL antibody, CBL2 antibody, RNF55 antibody.