ZNF198 contains nine MYM-type zinc fingers. The N-terminal half of the ZNF198 gene has been identified as a gene fused to the cytoplasmic domain of the fibroblast growth factor receptor (FGFR1) gene as a result of a t(8;13) (p11;q11-12) chromosomal rearrangement. The t(8;13) chromosomal translocation is associated with myeloproliferative diseases such as stem cell leukemia lymphoma syndrome (SCLL). Studies of the normal function of ZNF198 have revealed that it associates with HHR6 and RAD18 and may be involved in the repair of DNA. ZNF198 has also been found to associate with the BHC110 subunit of a histone-deacetylase containing corepressor complex and may have an additional function in transcriptional repression.
Alternative names for
ZNF198 Antibody include zinc-finger MYM-type protein 2 antibody, fused in myeloproliferative disorders protein antibody, ZMYM2 antibody, FIM antibody, RAMP antibody, SCLL antibody.